Sleep Supplements
Amino Acids



S-Adenosyl methionine (SAMe) is a naturally occurring molecule that is involved in numerous biochemical reactions in the body. SAMe is derived from the amino acid methionine and plays a role in the production of neurotransmitters, hormones, and other important biomolecules in the body. In addition, it is also involved in DNA methylation and is thought to have important anti-inflammatory and anti-aging effects. SAMe supplements are often taken for their antidepressant and anti-inflammatory effects. Because of its sleep neurotransmitter regulating performance, it can improve sleep quality, and there is research on its effect on Alzheimer’s and Parkinson’s.


plant-based, animal-product, synthetic


Milk, Eggs, Meat, Fish, Soybean, Vegetables, Synthetic


Amino Acids

Age range:

18-60, >60


May be toxic in high doses

What influence sleep problems

What are SAMe benefits?

Adenosyl methionine is a chemical that can help improve sleep. It acts as a neurotransmitter in the brain, helping to regulate mood and alertness. Adenosyl methionine can also help to decrease fatigue, increase energy, and improve sleep quality.

Table of relations

Dietary supplementConsistent EffectsStrength of EffectsScientific articles
See all 3 studies
See all 10 studies

SAMe and Anxiety

Anxiety is the body's natural response to stress. It's a feeling of fear or apprehension about what's to come. It can be triggered by a specific situation and not last long - which is very common and ok - or it can be a generalized disorder (which is considered a illness) that can bring harm to everyday life and also cause other conditions like depression.

SAMe and Depression

Depression is a chronic and recurrent psychiatric condition that produces mood changes characterized by deep sadness, mood swings, loss of interest in activities, causing significant impairment in daily life.

Other Amino Acids

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